Award
NIH Reporter #5R37GM071747-22
Mechanistic Studies of Replication Initiation in Prokaryotes
Recipient
Not specified
Award Amount
$408,052.00
Ceiling
$408,052.00
Awarded
June 03, 2026
Identifier
5R37GM071747-22
Research project studying DNA replication initiation mechanisms in bacteria to inform drug discovery.
Description
This project focuses on the molecular mechanisms of DNA replication initiation in bacteria, aiming to understand the structural organization of early-stage replisome formation and the regulatory principles involved. The research employs structural, biochemical, and single-molecule approaches to address fundamental questions in DNA replication and develop new drug-discovery strategies targeting bacterial initiation systems.