Award
National Institute of General Medical Sciences 1R35GM163846-01
Imaging Protein Synthesis on the Ribosome using Single-Molecule FRET
Recipient
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Award Amount
$678,370.00
Ceiling
$678,370.00
Awarded
April 27, 2026
Identifier
1R35GM163846-01
This award funds research to elucidate the mechanisms of protein synthesis on ribosomes in bacteria and humans, employing advanced imaging techniques to inform antibiotic and cancer therapy development.
Description
The project aims to define the elemental steps of elongation in bacterial and human protein synthesis using advanced biophysical methodologies including single-molecule fluorescence imaging and cryo-electron microscopy. It focuses on understanding mechanisms to develop better antibiotics and cancer therapies.