Award
National Institute of General Medical Sciences 1R35GM166420-01
Regulation of Tissue Barriers During Host Microbe Interactions
Recipient
Yale University
Award Amount
$462,000.00
Ceiling
$462,000.00
Awarded
July 27, 2026
Identifier
1R35GM166420-01
NIH grant awarded to Yale University for research on immune responses and tissue barrier regulation during host-microbe interactions using advanced genomics and genetic methods.
Description
This project aims to investigate how cell identity and tissue compartmentalization influence immune programs, focusing on the maintenance of host-microbe balance through physical and functional barriers. The research will utilize single-cell and spatial genomics, biosensors, and genetic approaches across plant species to map transcriptional and hormonal networks involved in microbial colonization, immune activation, and barrier integrity. The goal is to understand how local immune responses are organized at the cellular level and integrated into systemic protection, with implications for both plant and animal host-microbe interactions.