Award
National Institute of Allergy and Infectious Diseases 5R01AI137168-09
Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis
Recipient
Sloan-Kettering Inst Can Research, New York, NY, United States
Award Amount
$523,794.00
Ceiling
$523,794.00
Awarded
June 09, 2026
Identifier
5R01AI137168-09
Research project funded by NIAID to study molecular mechanisms linking cell homeostasis and innate immunity, focusing on inflammasome activation and potential therapeutic targets.
Description
This research project will study a molecular link between cell homeostasis and innate immunity. It aims to elucidate mechanisms controlling immunity, with implications for infectious disease, cancer, autoimmune, neurodegenerative, and metabolic disorders. The study focuses on inflammasomes, particularly NLRP1 and CARD8, and their activation via Xaa-Pro peptides and reductive stress, exploring their role in immune responses and potential therapeutic targets.