Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR081967-04
Role of serum advanced glycation end-products in altering tendon properties with diabetes
Recipient
Purdue University
Award Amount
$575,845.00
Ceiling
$575,845.00
Awarded
July 06, 2026
Identifier
5R01AR081967-04
NIH grant awarded to Purdue University to study the role of serum advanced glycation end-products in tendon complications related to diabetes, aiming to develop new treatment strategies.
Description
This project hypothesizes that increased serum advanced glycation end-products (AGEs), activating receptors for AGEs (RAGE), are a principal mechanism driving tendon complications in diabetes. The research aims to delineate the role of serum AGEs and RAGE activation in promoting tendon extracellular matrix (ECM) disorganization and biomechanical impairment, using mouse models and advanced imaging techniques such as ultrasound and MRI. The goal is to develop new treatment strategies to improve tendon function and reduce the clinical and economic burden of diabetic tendon complications.