Award
National Institute of General Medical Sciences 5R35GM155319-03
STUDIES ON FATTY ACID METABOLIZING CYTOCHROME P450 ENZYMES
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$376,787.00
Ceiling
$376,787.00
Awarded
April 08, 2026
Identifier
5R35GM155319-03
The award funds research on CYP4F enzymes to understand their roles in metabolism and disease, aiming to develop targeted therapies by studying their structure, function, and regulation.
Description
This project aims to characterize the structure and function of CYP4F enzymes, including their regulation by partner proteins and their isoform-specific substrate specificities, to facilitate their development as drug targets. The CYP4F family of fatty acid ω-hydroxylases includes isoforms involved in vitamin K and drug metabolism, ceramide production, and generating the lipid mediator 20-HETE from arachidonic acid, which regulates blood pressure and is linked to diseases like hypertension, traumatic brain injury, and cancer. The project will explore the functions of CYP4F isoforms, their regulation by partner proteins, and their structural properties to develop targeted therapies.