Award
National Cancer Institute 5P01CA257904-05
Project 2: Mitigation of radiation toxicity in treatment of sarcoma with FLASH vs. Standard dose rates
Recipient
University of Pennsylvania
Award Amount
$569,327.00
Ceiling
$569,327.00
Awarded
February 11, 2026
Identifier
5P01CA257904-05
The award funds research on FLASH proton therapy to reduce radiation toxicity in sarcoma treatment, involving preclinical and clinical studies to assess safety and efficacy.
Description
This project aims to develop and evaluate FLASH proton therapy as a means to reduce toxicity in sarcoma treatment, with potential applications across other cancers. It will elucidate mechanisms by which FLASH spares normal tissues through investigations in mice and determine the safety and efficacy of FLASH for treatment of dogs with osteosarcomas. The study includes in vivo mouse models, dose escalation studies, and a phase 1 clinical trial to evaluate safety, tolerability, and efficacy.