Award
National Institute of General Medical Sciences 2R15GM139150-02
Defining the Biochemical Function and Therapeutic Utility of Unique PARP14 and PARP15 ADP-Ribosylation Sites
Recipient
Santa Clara University, Chemistry Department, Santa Clara, CA, United States
Award Amount
$507,796.00
Ceiling
$507,796.00
Awarded
September 05, 2025
Identifier
2R15GM139150-02
NIH grant to study ADP-ribosylation mechanisms on PARP14 and PARP15, develop inhibitors targeting viral glycohydrolases, and map biochemical pathways involved in antiviral responses.
Description
This NIH-funded project aims to elucidate the biochemical roles of ADP-ribosylation, identify specific modification sites on key enzymes, and develop targeted inhibitors to modulate viral and cellular processes, with broad implications for medicine and cell biology.