Award
NIH Reporter #5R01HG013472-03
Genome-wide assessment of transcriptional state history
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$390,000.00
Ceiling
$390,000.00
Awarded
May 05, 2026
Identifier
5R01HG013472-03
Development of a genetic toolkit to record and analyze cellular transcriptional history for insights into development, cancer, and injury response.
Description
The project aims to develop a genome-wide record of transcriptional history using transcriptional endpoint marking (TEM), which introduces a permanent genetic mark at actively transcribed genes. This technology will enable the capture of past cellular states and developmental decisions, providing insights into cellular lineage, resistance mechanisms, metastasis, and response to treatments.