NIH Reporter #5DP1DK139958-03

High-dimensional chemical targeting of multiple neuron types to regulate energy balance

Award to develop machine-learning designed drug mixtures targeting neurons to regulate energy balance and promote weight loss, involving advanced imaging and in vivo testing.

Description

This project aims to test whether novel machine-learning methods can be used to design drug mixtures that activate or inhibit specific neurons involved in satiety, with the goal of reducing side effects and promoting weight loss. The approach involves using advanced imaging and single-cell sequencing to develop ligand mixtures that target multiple neuron subtypes, followed by in vivo testing in mouse models.

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