Award
National Institute of Environmental Health Sciences 5R01ES032806-05
Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine Particles
Recipient
University of California Los Angeles
Award Amount
$391,155.00
Ceiling
$391,155.00
Awarded
March 06, 2025
Identifier
5R01ES032806-05
Research project funded by the National Institute of Environmental Health Sciences to study how ultrafine particles in air pollution cause cardiovascular toxicity through lipid oxidation and macrophage activity, aiming to develop biomarkers and interventions.
Description
This project aims to dissect mechanisms how inhalation of particulate matter results in lipid peroxidation and atherosclerosis, contributing to cardiovascular diseases such as heart attacks and strokes. It investigates the role of alveolar macrophages and the Nrf2/Heme oxygenase 1 antioxidant axis in mediating cardiometabolic toxicity from air pollution.