Award
National Institute of General Medical Sciences 5R35GM148160-04
Cell and mechanobiology of Asymmetric Cell Division
Recipient
University of Washington
Award Amount
$376,659.00
Ceiling
$376,659.00
Awarded
December 19, 2025
Identifier
5R35GM148160-04
NIH grant awarded to University of Washington to study asymmetric cell division mechanisms in Drosophila neuroblasts using advanced imaging and molecular techniques.
Description
This project investigates mechanisms such as mechanical cues, sibling cell size asymmetry, and organelle asymmetry in asymmetric cell division (ACD), using Drosophila neuroblasts as a model. The research aims to understand how cortical flows, centrosome asymmetry, and biased segregation influence cell fate decisions, employing live cell imaging, superresolution microscopy, RNA sequencing, and optogenetics.