Award
NIH Reporter #11320905
Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants
Recipient
High Point University
Award Amount
$447,000.00
Ceiling
$447,000.00
Awarded
March 23, 2026
Identifier
11320905
This award funds research to develop selective ligands for dopamine D4 receptor variants to better understand their role in ADHD and substance use disorders and to aid medication development.
Description
The project aims to discover candidate medications and develop new molecular tools to study the dopamine D4 receptor (D4R) and its variants, including the common D4.4R variant and the ADHD- and substance use disorder-associated D4.7R minor variant. The goal is to develop selective compounds to understand D4R variant signaling and identify potential medication targets for ADHD and substance use disorders.