Award
NIH Reporter #4R01ES025750-07
Mechanisms of PhIP-induced dopaminergic neurotoxicity
Recipient
Purdue University
Award Amount
$597,756.00
Ceiling
$597,756.00
Awarded
August 13, 2026
Identifier
4R01ES025750-07
Research project funded to study how dietary toxicants like PhIP contribute to dopaminergic neurotoxicity relevant to Parkinson's disease, focusing on mechanisms such as neuromelanin interaction and mitochondrial dysfunction.
Description
This project investigates the role of dietary heterocyclic aromatic amines (HAAs), specifically 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in inducing neurotoxicity. The research aims to elucidate mechanisms involving neuromelanin, mitochondrial dysfunction, DNA adduct formation, and protein aggregation, which may contribute to Parkinson's disease pathogenesis.