Award
NIH Reporter #5R01AR080753-04
Stem Cell Dysfunction in Aged Skeletal Muscle
Recipient
University of Southern California, Los Angeles, CA
Award Amount
$531,924.00
Ceiling
$531,924.00
Awarded
July 06, 2026
Identifier
5R01AR080753-04
Research grant to study the FOS/NAD/ART1-MARylation pathway in muscle stem cells to restore muscle repair capacity in aged individuals.
Description
This project investigates a novel stem cell activation pathway involving FOS and ART1 that enhances muscle repair. It hypothesizes that misregulation of this pathway contributes to muscle deterioration with age and that correcting it can improve muscle health in the elderly.