Award
National Institute of Mental Health 1R21MH140123-01
A synaptogenic adhesion code for myelin specificity
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$429,000.00
Ceiling
$429,000.00
Awarded
May 19, 2025
Identifier
1R21MH140123-01
A research project funded by the National Institute of Mental Health to study the genetic and molecular basis of myelin formation in the brain and its connection to autism spectrum disorder, using advanced genetic techniques and zebrafish models.
Description
This project aims to understand how some genes linked to autism spectrum disorder (ASD) function in myelin formation. It focuses on the molecular mechanisms of myelination and its relation to neuropsychiatric disorders, utilizing zebrafish models and advanced genetic tools. The project involves creating transgenic reporters and loss-of-function mutations to investigate the role of specific genes in myelin formation and ASD-related abnormalities.