Award
National Institute of Neurological Disorders and Stroke 4R37NS122141-05
Neuromodulatory regulation of synaptic plasticity in spinal nociceptive circuits
Recipient
University of Cincinnati
Award Amount
$601,309.00
Ceiling
$601,309.00
Awarded
June 23, 2026
Identifier
4R37NS122141-05
This award supports research investigating the neuromodulatory regulation of synaptic plasticity in spinal nociceptive circuits to better understand mechanisms underlying chronic pain and develop novel interventional strategies.
Description
Project focused on understanding how neuromodulatory signals regulate synaptic plasticity in spinal nociceptive circuits, with implications for chronic pain treatment. The research aims to identify neuromodulatory signals that promote activity-dependent strengthening of sensory synapses onto spinal projection neurons and contribute to pain pathway priming after early life injury.