Award
National Institute of Allergy and Infectious Diseases 5R01AI177594-04
Pathogenic B cell:CD4 T cell interactions in a novel B cell-dependent EAE mouse model of multiple sclerosis
Recipient
University of Iowa
Award Amount
$472,369.00
Ceiling
$472,369.00
Awarded
July 09, 2026
Identifier
5R01AI177594-04
Research project studying the interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis to understand disease mechanisms and inform therapies.
Description
This project uses a novel B cell-dependent, antibody-independent EAE model to study B cell roles in shaping CD4 T cell responses and CNS B cell involvement in autoimmune demyelination. The research aims to understand how B cells influence pathogenic CD4 T cells via cytokine support and their interactions in the CNS, which could inform patient-specific therapies.