Award
National Institute of Allergy and Infectious Diseases 5R21AI183146-02
Alleviating antibiotic-induced gut dysbiosis by restoring small intestinal bile acid metabolism
Recipient
Brown University
Award Amount
$199,375.00
Ceiling
$199,375.00
Awarded
December 04, 2025
Identifier
5R21AI183146-02
The award supports research to investigate the role of bile acid metabolism disruption in antibiotic-induced gut dysbiosis and to develop therapeutic approaches to restore bile acid metabolism and protect the gut microbiome.
Description
This project aims to understand how antibiotic-induced disruption of bile acid metabolism in the small intestine contributes to gut microbiome damage and to develop interventions to restore bile acid metabolism to reduce antibiotic-associated microbiome damage.