Award
National Heart, Lung, and Blood Institute 1K08HL181477-01A1
Colon cancer mediates arterial remodeling through smooth muscle cell phenotypic changes via PDGFR-B signaling
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$163,285.00
Ceiling
$163,285.00
Awarded
June 25, 2026
Identifier
1K08HL181477-01A1
A multi-year NIH-funded project led by Caitlin Fox Bell at University of Colorado Denver studying the mechanisms linking colon cancer and vascular remodeling through PDGFR-B signaling, aiming to understand cardiovascular risks in colon cancer patients.
Description
This project investigates how colon cancer interacts with the vascular system, focusing on vascular remodeling and smooth muscle cell changes via PDGFR-B signaling. It aims to elucidate shared inherited modulators of risk for both colon cancer and cardiovascular disease using innovative cell and animal modeling, single cell transcriptomics, epigenetics, and large-scale human genetic data.