Award
National Heart, Lung, and Blood Institute 5K01HL177045-02
Circadian Regulation of Cardiomyocyte Size and Function
Recipient
University of Kentucky, Lexington, KY, United States
Award Amount
$144,909.00
Ceiling
$144,909.00
Awarded
February 10, 2026
Identifier
5K01HL177045-02
Research grant to study the circadian regulation of cardiomyocyte size and function using hiPSC-CMs, focusing on genetic mutations affecting circadian rhythms and cardiac health.
Description
The study aims to establish human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as models to investigate how the intrinsic cardiomyocyte circadian clock impacts cell size and function. It will explore whether inherited genetic mutations, such as those causing hypertrophic cardiomyopathy, disrupt circadian rhythms. The research will develop in vitro models to study circadian regulation independently of the suprachiasmatic nucleus (SCN), providing insights into cellular mechanisms governing cardiac health.