Award
National Heart, Lung, and Blood Institute 5R01HL151685-05
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
Recipient
Washington University, Saint Louis, MO
Award Amount
$710,780.00
Ceiling
$710,780.00
Awarded
January 03, 2025
Identifier
5R01HL151685-05
NIH awarded a grant to Washington University for developing a PET radiotracer to image CCR2+ monocytes in pulmonary fibrosis, aiming to monitor disease activity and treatment response in IPF patients.
Description
This project addresses the challenge of caring for patients with idiopathic pulmonary fibrosis (IPF), a lung disease with short survival and limited therapeutic options. The research involves developing a PET radiotracer, 64Cu-DOTA-ECL1i, to image CCR2+ monocytes involved in pulmonary fibrosis. The study aims to evaluate the radiotracer's ability to monitor inflammation and fibrosis in animal models and human patients, assess response to anti-fibrotic drugs, and validate CCR2+ cell detection in lung tissue.