Award
NIH Reporter #5R01HL166271-03
Inflammatory caspase activation in sickle cell disease
Recipient
Baylor College of Medicine, Houston, TX
Award Amount
$689,292.00
Ceiling
$689,292.00
Awarded
March 05, 2026
Identifier
5R01HL166271-03
This NIH grant supports research on inflammatory caspase activation in sickle cell disease, aiming to understand molecular mechanisms and develop therapies to reduce inflammation-related complications.
Description
Research grant to investigate how heme induces activation of caspase-4, its role in inflammation and organ injury in sickle cell disease, and its clinical implications in pediatric patients. The study involves identifying heme binding sites on caspase-4, using knockout mouse models, and analyzing patient data for markers of hemolysis and inflammation.