Award
NIH Reporter #1K99DK146120-01A1
Decoding Peripheral-to-Central Mechanisms Regulating Food Choices Following Long-Term Exercise
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$91,500.00
Ceiling
$91,500.00
Awarded
August 27, 2026
Identifier
1K99DK146120-01A1
The award supports research to understand how long-term exercise affects neural mechanisms that regulate sugar intake, aiming to develop therapies that mimic exercise benefits for metabolic diseases like diabetes.
Description
This project aims to elucidate the neurophysiological changes underlying exercise-induced reductions in sugar intake and identify therapeutic targets that can mimic these effects in metabolic diseases. The research focuses on how long-term exercise modifies gut-derived signals and their transmission to the brain to influence reward circuitry, with the goal of developing new therapeutic strategies to combat diabetes by reducing sugar consumption.