Award
NIH Reporter #10793060
Regulation of Cadherins by MLK3
Recipient
University of Toledo
Award Amount
$451,500.00
Ceiling
$451,500.00
Awarded
September 22, 2023
Identifier
10793060
This NIH-funded project studies how MLK3 regulates cell adhesion proteins in ovarian epithelial cells to understand mechanisms affecting cell adhesion, migration, and cancer progression.
Description
The project investigates the role of mixed-lineage kinase 3 (MLK3) in regulating cell-cell adhesion proteins E-cadherin and N-cadherin in ovarian epithelial cells. It aims to elucidate mechanisms by which MLK3 influences cell adhesion, migration, and invasion, which are critical for tissue morphogenesis and cancer progression.