Award
National Institute on Aging 1RF1AG091479-01A1
Evaluation of the neuroimmune mechanisms influencing therapeutic targeting potential of the LH/CG receptor in the menopausal and AD brain
Recipient
University of Florida, Gainesville, FL
Award Amount
$2,329,970.00
Ceiling
$2,329,970.00
Awarded
August 27, 2025
Identifier
1RF1AG091479-01A1
The award supports research on neuroimmune mechanisms and hormone receptor signaling in menopause and Alzheimer's disease, focusing on therapeutic targeting of the LH/CG receptor to modulate neuroinflammation and cognitive outcomes.
Description
This project expands understanding of neuroendocrine regulation of neuroinflammatory processes and may inform therapies for neurological conditions involving immune cell infiltration. It aims to evaluate the cell-specific role of LHCGR signaling, its involvement in peripheral infiltration mechanisms, and how age and reproductive status influence therapeutic outcomes in the context of menopause and Alzheimer's disease.