Award
Veterans Health Administration 5IK2BX005828-04
A Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction
Recipient
Veterans Health Administration
Awarded
July 30, 2026
Identifier
5IK2BX005828-04
Research project awarded by Veterans Health Administration to study the role of NPRC in heart failure with preserved ejection fraction, focusing on obesity-induced HFpEF and right ventricular failure, using transgenic mouse models and human stem cells.
Description
This project focuses on studying the role of the natriuretic peptide clearance receptor NPRC in heart failure with preserved ejection fraction (HFpEF), with a focus on obesity-induced HFpEF and right ventricular failure. The project aims to test a promising new therapeutic target, NPRC, in the context of HFpEF, utilizing transgenic mouse models and human induced pluripotent stem cells. The project includes training objectives for techniques in mitochondrial function, gene editing, and stem cell differentiation.