Award
National Institute of Dental and Craniofacial Research 1R21DE035645-01A1
Treatment for Medication-related Osteonecrosis of the Jaw in Rice Rats via In Situ Delivery of an Anti-Inflammatory Enzyme with Spatial Metabolome/Glycome Profiling of Disease Progression and Therapy
Recipient
UNIVERSITY OF FLORIDA
Award Amount
$428,188.00
Ceiling
$428,188.00
Awarded
July 14, 2026
Identifier
1R21DE035645-01A1
NIH awarded a grant to the University of Florida for research on treating medication-related osteonecrosis of the jaw in rice rats using an anti-inflammatory enzyme and spatial metabolome/glycome profiling.
Description
This is a NIH grant project focusing on a novel therapeutic strategy for MRONJ using local delivery of an engineered IDO-Gal3 fusion protein in a rice rat model. The project aims to reduce MRONJ prevalence and understand spatial metabolome/glycome profiles associated with the disease.