Award
National Institute of General Medical Sciences 2R15GM134457-02
Accessing Carbon-based S(VI) compounds via Sulfur-Fluorine (SuFEx) Exchange Reactions
Recipient
Pomona College
Award Amount
$428,004.00
Ceiling
$428,004.00
Awarded
July 23, 2025
Identifier
2R15GM134457-02
This award funds research to develop new synthetic methods using sulfur-fluorine exchange chemistry to create sulfonylated compounds for drug discovery, involving undergraduate research and aiming to reduce pharmaceutical costs.
Description
The project involves developing new methods to introduce key structural motifs into bioactive molecules relevant to public health. It aims to expand libraries of drug targets and lower pharmaceutical production costs. The work engages undergraduate students in synthetic chemistry research, focusing on sulfur-fluorine exchange (SuFEx) chemistry to synthesize sulfonylated compounds using affordable catalysts and metal bases.