Award
NIH Reporter #5R35GM124725-10
From intra to intercellular regulatory networks that define cell type identity
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$458,500.00
Ceiling
$458,500.00
Awarded
July 17, 2026
Identifier
5R35GM124725-10
Award to Johns Hopkins University by NIGMS to develop computational and experimental approaches for understanding and engineering cell fate through regulatory networks and signaling pathways, enhancing disease modeling and regenerative medicine.
Description
This project aims to improve the fidelity of cell fate engineering by developing computational tools to understand and manipulate the biological networks governing development, focusing on cell types related to the synovial joint. It involves extending computational methods, improving regulatory network tools, developing methods for generating reliable cell fate recipes, and investigating signaling pathways' influence on differentiation.