Award
National Institute of General Medical Sciences 1R35GM165612-01
Molecular determinants of lipid-protein recognition
Recipient
University of California, San Diego
Award Amount
$384,394.00
Ceiling
$384,394.00
Awarded
July 13, 2026
Identifier
1R35GM165612-01
Research project funded by the National Institute of General Medical Sciences to study lipid-protein interactions using computational and experimental methods, aiming to understand disease mechanisms and develop biosensors.
Description
This project investigates the biophysical interactions of lipid headgroups with membrane-associated proteins, focusing on their role in cellular homeostasis and disease. It employs deep learning, molecular dynamics simulation, and de novo protein design to model and predict protein-lipid interactions, with applications in understanding diseases like Niemann-Pick Disease Type C and developing biosensors.