Award
NIH Reporter #4R37CA252050-06
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
Recipient
Fred Hutchinson Cancer Center, Seattle, WA, United States
Award Amount
$467,377.00
Ceiling
$467,377.00
Awarded
April 02, 2026
Identifier
4R37CA252050-06
Research project focused on understanding RIT1-driven lung cancer and developing new therapeutic strategies targeting RIT1 mutations.
Description
This work characterizes the mechanism of a little-studied new cancer oncogene, RIT1, and tests two new therapeutic strategies for the treatment of RIT1-mutant lung cancer. The project aims to advance understanding of RIT1 mutations in cancer and develop new therapeutic options involving preclinical studies, functional genomics, and potential clinical translation.