Award
National Heart, Lung, and Blood Institute 5R35HL139860-07
Systematic Investigation of Protein Ubiquitination in ARDS
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$920,220.00
Ceiling
$920,220.00
Awarded
December 15, 2023
Identifier
5R35HL139860-07
A research project funded by the National Heart Lung and Blood Institute to investigate protein ubiquitination in ARDS, aiming to discover new therapeutic targets to reduce morbidity and mortality associated with the syndrome.
Description
This project aims to systematically analyze protein ubiquitination networks in Acute Respiratory Distress Syndrome (ARDS) to identify molecular pathways that modulate inflammation, mitochondrial function/mitophagy, and DAMPs/inflammasome activation, and develop therapeutics targeting these pathways.