Award
NIH Reporter #5R21ES035517-02
Programming of Epigenetic Clocks and Biomarkers from Early-life Arsenic Exposure
Recipient
Stanford University
Award Amount
$232,708.00
Ceiling
$232,708.00
Awarded
August 14, 2024
Identifier
5R21ES035517-02
A research project funded by NIEHS to investigate how early-life arsenic exposure affects epigenetic biomarkers and aging, leveraging a natural experiment in Chile with historical high arsenic water exposure, aiming to understand long-term health impacts.
Description
This project studies the persistent epigenetic effects of early-life arsenic exposure using samples from a large epidemiological study in Antofagasta, Chile, where high arsenic water concentrations occurred between 1958 and 1970. The research aims to evaluate accelerated epigenetic aging and DNA methylation changes decades after exposure, controlling for various covariates, to understand the link between arsenic exposure and long-term health effects including cancer and chronic diseases.