Award
National Institute of Allergy and Infectious Diseases 4R01AI165870-03
Peptide-dependent mobilization of CD8 regulatory cells in cardiac transplantation
Recipient
Brigham and Women's Hospital
Award Amount
$1,318,506.00
Ceiling
$1,318,506.00
Awarded
August 19, 2025
Identifier
4R01AI165870-03
The NIH-funded research project aims to understand and manipulate CD8 regulatory T cells using synthetic peptides to reduce antibody-mediated rejection in cardiac transplantation, potentially improving graft survival.
Description
This project investigates the regulation of alloimmune responses in organ transplantation, focusing on CD8 regulatory T cells and synthetic peptides to inhibit antibody responses and improve graft survival.