Award
National Heart, Lung, and Blood Institute 5R00HL148523-05
Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human hearts
Recipient
State University of New York at Buffalo, Amherst, NY, United States
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
February 24, 2025
Identifier
5R00HL148523-05
The project investigates how obesity-related epicardial adiposity influences ventricular tachyarrhythmias in donor human hearts, aiming to develop new markers to predict and treat these arrhythmias.
Description
This project aims to use a multimodal and multiscale approach to characterize VT/VF in donor human hearts associated with sustained obesity, investigating the role of epicardial adiposity in promoting VT/VF via paracrine signaling and generating arrhythmogenic triggers.