National Institute of Neurological Disorders and Stroke 1K99NS146613-01

A Synaptic Basis for Dopamine-Driven Reinforcement Learning in Cortex

NIH grant awarded to Columbia University Health Sciences to study dopamine's role in synaptic plasticity and reinforcement learning in the cortex, using advanced imaging and neural manipulation techniques.

Description

This project investigates how dopamine influences synaptic connectivity and activity within cortical networks to understand reinforcement learning mechanisms. Using cutting-edge in vivo imaging and brain-machine interface paradigms, the research aims to elucidate the synaptic mechanisms underlying dopamine-driven reinforcement learning, with potential implications for disorders such as Parkinson’s disease, addiction, and schizophrenia.

View original record