Award
National Institute of General Medical Sciences 5R01GM145700-04
virtual compound screening using gene expression
Recipient
Michigan State University, East Lansing, MI
Award Amount
$420,807.00
Ceiling
$420,807.00
Awarded
August 14, 2025
Identifier
5R01GM145700-04
NIH grant awarded to Michigan State University for developing machine learning methods to predict drug-gene expression profiles to aid in drug discovery and lead optimization.
Description
This NIH grant project aims to develop novel data science approaches to leverage emerging gene expression profiles to discover novel drugs. The project involves developing machine learning methods to predict drug-gene expression and applying these methods to drug discovery, including screening compounds for liver cancer inhibitors, SARS-CoV-2 inhibitors, and cell reprogramming regulators, as well as lead optimization.