# NIH Reporter #2R56NS114289-06A1

Determining mechanisms regulating TDP-43 pathology, the link between aggregation and dysfunction

**Recipient:** Saint Louis University

**Award Amount:** $568,590.00
**Ceiling:** $568,590.00

**Awarded:** September 17, 2026

**Identifier:** 2R56NS114289-06A1

Funding supports research into mechanisms linking TDP-43 aggregation, nuclear depletion, and dysfunction, with the goal of identifying disease mechanisms and potential therapeutic and diagnostic strategies.

### Description

NIH project studying how TDP-43 aggregation causes loss of function and contributes to neurodegenerative disorders, including ALS and Frontotemporal Dementia.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11606638)