Award
National Institute of Neurological Disorders and Stroke 5R01NS107671-07
Therapeutic small molecule modulation of Kv channels
Recipient
University of California-Irvine
Award Amount
$494,045.00
Ceiling
$494,045.00
Awarded
July 24, 2026
Identifier
5R01NS107671-07
Award for research on small molecule modulation of Kv channels to develop therapies for neurological disorders such as ataxia, epilepsy, and addiction, funded by NINDS and conducted by University of California-Irvine.
Description
This project focuses on defining mechanisms of ligand activation of voltage-dependent potassium channels, discovering new potassium channel openers, and developing novel therapies for disorders including ataxia, epilepsy, and addiction. It involves research on plant-derived diterpenes and hydroxybenzoic acids that act as potent openers of neuronal Kv7 and Kv1 channels with potential therapeutic applications.