Award
National Cancer Institute 5R01CA289812-02
Defining the landscape of bacterial-colonized microniches in tumors and their role in intratumoral heterogeneity.
Recipient
University of TX MD Anderson Cancer Center
Award Amount
$620,787.00
Ceiling
$620,787.00
Awarded
August 26, 2025
Identifier
5R01CA289812-02
The project aims to understand how bacterial communities within tumors contribute to intratumoral heterogeneity and therapy resistance by mapping cellular and metabolic features and examining their role in remodeling the tumor microenvironment.
Description
This project seeks to map the intricate cellular and metabolic landscape of tumor bacterial-colonized microniches (BCMs) and their surrounding immune environment to advance mechanistic understanding of host-microbiota interactions within the tumor microenvironment (TME), potentially revealing novel approaches for cancer prevention and treatment.