Award
National Institutes of Health PA-23-271
The Interplay Between mTOR Inhibitors and Endothelial Cell-to-Cell Junction Dynamics: Implications for Vascular Barrier Dysfunction
Recipient
University of Maryland, College Park
Award Amount
$18,988.00
Ceiling
$18,988.00
Awarded
January 27, 2026
Identifier
PA-23-271
NIH grant awarded to University of Maryland, College Park for research on mTOR inhibitors' effects on endothelial cell junctions and vascular barrier dysfunction.
Description
This NIH grant supports research on the effects of mTOR inhibitors on vascular endothelial cell junctions, aiming to improve understanding of endothelial barrier dysfunction and inform translational applications. The project involves analyzing the impact of EVL and Torin-2 inhibitors on ECJs, morphology, and cell-cell adhesion, with a focus on live-imaging and permeability assays.