Award
National Heart, Lung, and Blood Institute 5R01HL124233-09
Using Integrative Genomics To Identify and Characterize Emphysema-Associated eQTL
Recipient
BRIGHAM AND WOMEN'S HOSPITAL, Boston, MA, United States
Award Amount
$711,689.00
Ceiling
$711,689.00
Awarded
September 05, 2024
Identifier
5R01HL124233-09
Research project funded by the National Heart Lung and Blood Institute to identify genetic variants associated with COPD by studying alternative splicing mechanisms using RNA sequencing, aiming to uncover new treatments for COPD.
Description
This project aims to identify genetic variants that influence COPD through mechanisms such as alternative splicing, using advanced RNA sequencing techniques. The research involves genome-wide discovery of splicing QTLs (sQTLs), differential isoform expression analysis, and functional validation of genetic variants affecting splicing in lung cells.