Award
NIH Reporter #5R01HL160921-04
Hyperglycemia and Adverse Pregnancy Outcome Study-Cardiovascular Health of HAPO Offspring (HAPO CVH)
Recipient
National Heart Lung and Blood Institute (NHLBI)
Award Amount
$1,762,069.00
Ceiling
$1,762,069.00
Awarded
June 01, 2026
Identifier
5R01HL160921-04
NIH awarded $1,762,069 to study the impact of maternal metabolic health during pregnancy on offspring cardiovascular health using the HAPO cohort, including epigenetic mechanisms.
Description
The project focuses on investigating the in utero environment's impact on cardiovascular health in offspring, leveraging the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study cohort. The study aims to define associations between maternal metabolic health during pregnancy and offspring cardiovascular outcomes, including subclinical CVD and carotid artery changes. It also explores epigenetic mechanisms mediating these associations. The project is funded by NIH and involves extensive data collection, including blood pressure, lipid profiles, ultrasonography, and DNA methylation analysis.