Award
NIH Reporter #3R01HL173346-03S1
Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power Output
Recipient
University of Michigan at Ann Arbor
Award Amount
$289,278.00
Ceiling
$289,278.00
Awarded
September 01, 2026
Identifier
3R01HL173346-03S1
A research project funded by the National Heart Lung and Blood Institute to develop and test a multi-scale computational model of cardiac metabolism and mechanics to understand limitations in cardiac power output and exercise capacity in heart failure patients.
Description
This project aims to develop a comprehensive multi-scale model to analyze the metabolic and mechanical factors influencing cardiac reserve and exercise capacity, particularly in the context of heart failure. The study involves computational simulations based on human phenotyping data and aims to identify intrinsic versus extrinsic limitations to cardiac performance.