Award
NIH Reporter #4R01CA280833-04
Unlocking the Chemical Space of Cancer-Associated Perturbations
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$863,577.00
Ceiling
$863,577.00
Awarded
August 25, 2025
Identifier
4R01CA280833-04
Development of the PEAR platform to profile tumor proteomes for understanding cancer cell responses to therapeutics and identifying targets for precision oncology.
Description
This project aims to develop the Probe Enabled Activity Reporting (PEAR) platform to profile tumor proteomes using chemical biology approaches. The goal is to understand proteomic changes in cancer cells in response to therapeutics, identify proteomic liabilities, and facilitate the discovery of targeted therapies. The research focuses on the molecular complexity of tumor biology, integrating chemical probes to visualize and identify protein targets, and unraveling tumor cell adaptations to improve drug discovery and precision oncology.