Award
National Institute on Drug Abuse 5R01DA058020-03
Mechanisms and Regulations of kappa Opioid Receptor Signaling
Recipient
Washington University, Saint Louis, MO
Award Amount
$457,055.00
Ceiling
$457,055.00
Awarded
March 26, 2026
Identifier
5R01DA058020-03
NIH research grant awarded to Washington University to study kappa opioid receptor signaling mechanisms and regulation, aiming to develop new opioid alternatives.
Description
This project aims to investigate the mechanisms and regulators that control kappa opioid receptor (KOR) signaling, focusing on non-traditional signaling networks at the cellular level. The research explores ligand-specific responses, G protein subtypes, β-arrestins, and the role of GPCR kinases such as GRK2 in receptor regulation to develop new chemical modulators as opioid alternatives and gain insights into KOR pharmacology.