Award
National Institute of Allergy and Infectious Diseases 5R01AI171408-04
The role of mammarenavirus defective interfering particles in protecting host fitness and the host-driven post-translational modifications that regulate their formation and function
Recipient
University of Vermont & St. College
Award Amount
$598,271.00
Ceiling
$598,271.00
Awarded
August 21, 2025
Identifier
5R01AI171408-04
This award supports research to understand how mammarenavirus defective interfering particles are regulated by host cellular processes and their role in viral persistence and host fitness, with implications for zoonotic transmission and viral pathogenesis.
Description
The project aims to identify cellular processes regulating mammarenavirus defective interfering particles (DIPs) and their impact on reservoir host fitness. It involves studying host pathways such as tyrosine kinases and ubiquitin ligases, mapping post-translational modifications, and modeling persistent and acute infections in rodents and humans.