Award
National Institute of Allergy and Infectious Diseases 5R01AI168178-05
Structural interrogation of vaccine- and infection-induced B cell responses
Recipient
ICHAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$780,825.00
Ceiling
$780,825.00
Awarded
January 06, 2026
Identifier
5R01AI168178-05
The project focuses on understanding immune imprinting and memory recall at a molecular level by mapping antibody epitopes onto protein structures, using SARS-CoV-2 as a model to inform better vaccination strategies against evolving viral pathogens.
Description
This project aims to elucidate the structural features of immune imprinting and antibody responses to SARS-CoV-2 and other coronaviruses, leveraging cryo-EM and single-cell analysis to inform vaccine design and understanding of immune evasion mechanisms.