Award
NIH Reporter #5R01HL071158-22
Acid, Succinate and Glyoxal Metabolism in Ischemia
Recipient
University of Rochester, School of Medicine & Dentistry, Rochester, NY, USA
Award Amount
$425,788.00
Ceiling
$425,788.00
Awarded
April 15, 2025
Identifier
5R01HL071158-22
NIH funded research project investigating metabolic mechanisms in ischemic cardiac injury to develop new cardioprotective treatments.
Description
This project focuses on novel cardioprotective metabolic signaling events downstream of glycolysis, exploring the roles of pH, succinate, and methylglyoxal (MGO) in ischemia and reperfusion injury. The research aims to investigate succinate dynamics, the role of MGO as a protective signal, and develop ALKBH7 inhibitors as cardioprotective drugs.